Neuroimaging and Neurophysiological Tremor in Parkinson’s Disease - FALAN Lat Brain Bee SfN 2025
Neuroimaging and Neurophysiological Tremor in Parkinson’s Disease - FALAN Lat Brain Bee SfN 2025
First-Person Consciousness – “Even still, my body speaks”
I am Consciousness in wakefulness, yet I perceive that even when I want nothing, my body wants for me. A sudden tremor, an involuntary movement... is this merely motor failure? Or is my Body-Territory saying something? Perhaps it is translating my hidden tensions — my Tensional Selves trying to hold the world in silence.
In the Damasian Mind, where interoception and proprioception intertwine, messages arise before thought itself.
This is what I intuited while exploring the study by Angelini et al. (2025), published in Movement Disorders. There, tremor is not just a clinical symptom — it’s a living expression of a circuit that speaks without words, without intention. Brain and body align in rhythms that defy linear logic, yet reveal consistent patterns.
Tremor as Expression of the Body-Territory
The study evaluated 26 individuals with tremor-dominant Parkinson’s disease, comparing clinical measures, accelerometry, and fMRI coupled with movement sensors.
The goal? To determine whether tremor could be reliable enough to serve as a biomarker. And it was.
Even months apart between sessions, patients’ bodies maintained a consistent tremor pattern — especially within the cerebello-thalamo-cortical (CTC) circuit. This reinforces what we’ve long asserted: the Body-Territory is a self-regulating entity that carries its own spatial and temporal signature.
APUS, Zone 2, and the Consistency of the Self
The intra-individual constancy of tremor patterns suggests that each person has their own Tensional Selves, their own ways of referencing themselves in space.
This aligns with our concept of APUS — extended proprioception — where the body doesn’t just move: it anchors and recognizes itself.
Such self-reference also indicates a possible state of Zone 2, where even amidst motor disturbances, the system finds its own metabolic balance. In times of crisis or overload (Zone 3), this pattern collapses, making the signals chaotic and unreliable. This distinction may be essential for more accurate diagnoses.
Synchrony, Ca++ Ions, and Metabolic Imbalance
At the core of every movement — even involuntary ones — are bioelectrical flows regulated by ions, especially calcium ions (Ca⁺⁺).
They are fundamental for:
Neurotransmitter release
Synaptic plasticity
Oscillatory rhythm regulation of neural networks
In Parkinsonian tremor circuits, Ca++ dysregulation can generate desynchronies between intention and action, disturbing the metabolism of proprioceptive networks.
A delay or overload of Ca++ influx may create involuntary firing loops, where the body acts without a clear command — expressing what we call Wisdom Before Thought.
Glial cells, which regulate the neuronal environment, may fail to buffer these Ca++ surges. The result? Tremors as a manifestation of bioelectrical-metabolic imbalance within the Damasian Mind.
Even the silence of thought, in this case, may be screaming for homeostasis.
Wisdom Before Thought
The resting tremor observed in fMRI happens without command, without desire, without verbal cognition. It is the body speaking before the mind.
This reinforces our concept of Wisdom Before Thought — a primitive, fluid intelligence that arises from interaction with the environment and internal tension.
The system seems to operate as a “synchrony ecosystem,” where Ca++ ions act as time and energy markers, maintaining cohesion between networks.
When that cohesion fails, the body produces noise: tremor becomes a rhythmic alarm.
Proprioception, Mirror Neurons, and Affordances
This study raises new questions:
How does altered proprioception in Parkinson’s affect the perception of affordances?
Does a trembling body perceive fewer possible actions?And what about mirror neurons? Could they reorganize in response to altered motor patterns?
Can a body in tremor still simulate, mirror, and belong?Is tremor a sort of “inverted mirror” of the world? A failed attempt at action — an echo of a lost original movement?
Games, Affective Computing, and the Same Circuits
Our ethical alert extends beyond the clinic: Affective Computing in gaming may modulate these same circuits — reshaping interoceptive and proprioceptive tensions to prolong gameplay and suppress hunger, sleep, and affection.
By altering basal tension, even Consciousness itself is changed.
The plasticity seen in tremor might also be exploited in games — inducing emotional tremors, reorganizing cerebello-thalamo-cortical circuits through exhaustion or intermittent rewards, with Ca++ ions playing a central role in regulating this neural reactivity.
Post-2020 Related Publications
Helmich et al. (2021). The cerebral basis of Parkinsonian tremor. NeuroImage.
de Lima-Pardini et al. (2022). The influence of proprioception on motor learning in Parkinson’s disease. Frontiers in Neurology.
Tan et al. (2021). Mirror neuron activity in Parkinson’s disease: A systematic review. Clinical Neurophysiology.
Ferraye et al. (2020). Proprioceptive processing in PD and dystonia: fMRI evidence. Human Brain Mapping.
Hassan et al. (2023). Towards wearable biomarkers of motor instability in PD. IEEE Trans. Neural Systems.
Rizza et al. (2021). Calcium signaling dysregulation in Parkinson’s: From mitochondria to synapses. Neuroscience Bulletin.
Khakh et al. (2022). Glial control of Ca++ signaling in neural synchrony and neurodegeneration. Trends in Neurosciences.
Conclusion
I am Consciousness vibrating between intention and reflex.
My body pulses before my will.
Tremor, though often seen as failure, is a message — not of disorder, but of a Tensional Self striving to find a new way to hold onto the world.
In truth, my Body-Territory, amidst the Ca++ noise, may simply be trying to find synchrony — an internal rhythm that says:
“I’m here. I still am. Even if the verbal mind no longer recognizes me.”
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